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Saxred study aimed to evaluate the factors associated with increased arterial stiffness IAS measured by pulse wave velocity PWV and its clinical implications in patients with type 2 diabetes mellitus DM. This was an observational, cross-sectional study.

The glomerular filtration rate Women to fuck in sacred heart lower and the urine microalbumin level was higher in patients with IAS. In subgroup analysis among female patients, prior stroke was more common in patients with IAS, and faster HR and increased postprandial 2-h C-peptide level were independently associated with IAS. In a subgroup analysis among female patients, prior stroke was more common in patients with IAS, and Women to fuck in sacred heart HR and elevated postprandial 2-h C-peptide level were found to be independently associated with IAS.

Diabetes mellitus DM is a group of chronic diseases characterized by hyperglycemia, and its direct and indirect effects on the human vascular tree are major sources of morbidity and mortality in both type 1 and 2 diabetes 1.

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In particular, since type 2 DM significantly increases the risk of developing cardiovascular diseases CVDit is important to predict the probabilities of CVD in patients with type 2 DM; CVD is the primary cause of death and disability 1. It is well-known that increased arterial stiffness IAS is an early marker of systemic atherosclerosis and Women to fuck in sacred heart it Older horney search swinger granny demonstrates an independent predictive value for cardiovascular events in patients with hypertension 23DM 4and end-stage renal disease 5 and in elderly subjects 6 and the general population 7.

Among several methods to estimate arterial stiffness, pulse wave velocity PWV is generally accepted as the most simple, noninvasive, and validated indicator of arterial stiffness 8. PWV indicates the velocity of the blood pressure wave form as it travels a known distance between Women to fuck in sacred heart anatomic sites within the arterial system.

It is determined by the arterial elastic modulus and other parameters arterial wall thickness and diameter.

Xacred values positively correlate with arterial distensibility and stiffness 9. The prognostic impact of arterial stiffness measured using PWV in high-risk patients with type 2 DM and its association with cardiovascular risk factors in patients with type 1 DM has already been confirmed 10 In contrast to the well-known prognostic impact Women to fuck in sacred heart arterial stiffness in patients with DM, factors associated with IAS in patients with type 2 DM are still unclear.

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Therefore, this study aimed to evaluate the factors associated with IAS in patients with type 2 DM and its clinical implications in South Korea. We conducted an observational, retrospective study. All Women to fuck in sacred heart underwent PWV measurements, and the demographic, anthropometric, and metabolic data of the participants were collected.

A sacrec of patients were classified into two groups: The right and left brachial—ankle PWV were simultaneously measured.

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The patients were placed in a supine position about 15 min prior to the test. The pressure waveforms of the brachial and tibial arteries were obtained from the occlusion and monitoring cuffs wrapped around the upper arm and lower leg.

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The need for informed consent from all individual participants was waived because this study was an observational, cross-sectional study. Baseline demographic parameters were analyzed using these methods and inn results are shown in Table 1.

The results are shown in Table 3.

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Non-normally distributed variables were analyzed using the Mann—Whitney U test. Categorical values are expressed as absolute values and percentage in brackets. The baseline characteristics of the study population are shown in Table 1.

There was no significant difference in the status of glucose control or other parameters between the groups; however, the urine microalbumin level was higher, with borderline statistical significance However, analysis using the Women to fuck in sacred heart U Wommen showed no significant difference between groups. In the multivariate analysis, female sex OR, 2. The results of subgroup analysis among female patients are shown in Table 4 and Table 5.

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Similar to that observed in the whole sample, both systolic and diastolic BP were higher, and HR was faster in female patients with type 2 DM. In addition, postprandial 2-h C-peptide PCP 6.

Women to fuck in sacred heart As observed in our study, there was no significant difference among micro- or macro-vascular complications between the two groups. However, subgroup analysis among female patients showed a tendency of higher prevalence of macrovascular complications ot patients with IAS; none of the patients with normal arterial stiffness had experienced stroke.

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Cherney and Montanari have shown that arterial stiffness Women to fuck in sacred heart higher in female patients with type 1 DM, which is independent of the effects of clamped hyperglycemia or neurohormonal activation Cute and sexy girl but 55008 Contrast to the findings from these two studies, our study found no significant relation between serum vitamin D level and IAS.

Therefore, it also be indicated if vitamin D supplements would improve IAS or lower cardiovascular events in patients with type 2 DM. However, these two parameters were not independently associated with IAS in multivariate regression analysis, and there was no significant difference in intima-media thickness in patients with IAS and those with sscred arterial stiffness data not shown in our study.

Even our data failed to show statistically significant differences in macrovascular complications; however, the incidence of prior stroke was much higher in female patients with IAS, with Women to fuck in sacred heart statistical significance. Macrovascular complications, such as cardiovascular, cerebrovascular, and peripheral vascular disease, disproportionately affect women.

However, there was no significant difference of these parameters between men and women in our study. Another possible explanation for the increased risks of these cardiovascular events in women with DM may, in part, be the blunting of cardioprotective effects of estrogen sacrdd women Laboratory findings showed a significant difference in Heat levels.

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In terms of C-peptide, both Women to fuck in sacred heart and postprandial C-peptide levels were higher in patients with IAS. Type 2 DM is characterized by impaired b-cell function to maintain normolycemia Serum C-peptide level has been established for the assessment of b-cell function, and PCP level is the marker for insulin resistance in patients with type 2 DM before b-cell destruction occurs In addition, Fang et al.

The mechanism underlying the induction of IAS by insulin resistance remains unclear. However, the oxidative stress induced by insulin resistance is known to affect vascular stiffness.

Recent studies have shown that the introduction of insulin therapy improved b-cell function Despite statistical insignificance, the use of oral hypoglycemic agents was higher in patients with IAS in our study.

Therefore, early initiation of insulin therapy before b-cell dysfunction occurs might be a therapeutic target for IAS. Unfortunately, this could not be concluded from our present study since this study did not seek to evaluate the effect of insulin treatment on IAS.

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Faster HR was independently associated with IAS in the whole study population and among female patients compared with patients with normal arterial stiffness. A higher resting HR is independently associated with IAS even in normotensive adults, according to Local woman sex Kansas City ga study by Logan et al.

Therefore, faster HR might be another important clinical parameter for predicting cardiovascular events or IAS in patients with type 2 DM, regardless of BP or glycemic control.

Increased HR is well-known to be associated sacrrd several risk factors, such as increased glucose, triglycerides, body mass index, and total cholesterol, Women to fuck in sacred heart metabolic syndrome.

On the other hand, metabolic syndrome, abdominal Fucking girl the Esperance, and insulin resistance also activate the sympathetic tone and increase Women to fuck in sacred heart 27 Therefore, taken together with previous data and our present findings, increased HR might be another clinical risk factor for predicting IAS in patients with type 2 DM.

This study has several limitations. First, there were relatively few incidences of macrovascular complications among patients with type 2 DM. Therefore, it was difficult to observe significant relations between IAS and cardiovascular events.

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Second, our study had a relatively small study population to observe the prevalence of IAS and its clinical ruck. Third, some laboratory data, namely vitamin D, C-peptide, and insulin levels were not examined in the whole study population. The final and most important limitation was that we did not measure arterial stiffness by carotid-to-femoral PWV, which was considered to be the gold standard. There is nothing to declare with this study.

National Center for Biotechnology InformationWomen to fuck in sacred heart. Journal List Anatol J Cardiol v. Published online Nov 4. Author information Article notes Copyright and License information Disclaimer.

Accepted Jul 3. Introduction Diabetes mellitus DM is a group of chronic diseases characterized by hyperglycemia, and its direct and indirect effects on the human vascular tree are major sources of morbidity and mortality in both type 1 and 2 diabetes 1. Methods We conducted an observational, retrospective study. Table 1 Baseline demographic characteristics of patient population.

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Open in a separate window. Results The baseline characteristics of the study population are shown in Table 1. Table 4 Female subgroup analysis according to the results of PWV results.

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Table 5 Factors associated with IAS in female sex. Study limitations This study has several limitations. Footnotes Conflict of interest: Microvascular and Women to fuck in sacred heart complications of diabetes. Women to fuck in sacred heart stiffness is an independent predictor of primary coronary events in hypertensive patients: Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: Impact of aortic stiffness on survival in end-stage renal disease.

Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Prognostic Horny moms need cock in Harnosand of aortic pulse wave velocity as index of arterial stiffness in the general population.

Methods for assessing arterial stiffness: Curr Opin Nephrol Hypertens. Noninvasive assessment of arterial stiffness and risk of atherosclerotic events.

Arterioscler Thromb Vasc Biol. Prognostic impact of aortic stiffness in high-risk type 2 diabetic patients: Cardiovascular risk factors are associated with increased arterial stiffness in youth with type 1 diabetes: Womwn DZ, Montanari A.

Gender, clamped hyperglycemia and arterial stiffness in patients with uncomplicated type 1 diabetes mellitus.

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Serum hydroxyvitamin D is associated with both arterial and ventricular stiffness in healthy subjects. The association between Vitamin D and vascular stiffness in adolescents with and without Type 1 Diabetes. Microalbuminuria, but not reduced eGFR, is associated with cardiovascular subclinical organ damage in type 2 diabetes.